Enfermedad de Pompe y compromiso respiratorio

Introducción: El compromiso respiratorio en la enfermedad de Pompe es una de sus manifestaciones más frecuentes, tiene un impacto negativo en la calidad de vida y facilita la aparición de múltiples complicaciones. Se puede presentar como parte evolutiva de la enfermedad o incluso ser el síntoma inicial de la patología. Contenidos: La presentación clínica del compromiso respiratorio en la enfermedad de Pompe se caracteriza por disnea, ortopnea, cefalea y tos, y sus cambios paraclínicos incluyen hipercapnia, policitemia, elevación del índice de apnea/hipopnea, así como disminución de la capacidad vital y de las presiones inspiratoria y espiratorias máximas. El compromiso respiratorio es causado principalmente por disfunción muscular (especialmente el diafragma) y alteración de la regulación del sistema nervioso central. Conclusiones: Es fundamental la valoración acuciosa inicial de los patrones respiratorios y por supuesto su seguimiento, el cual dependerá del tipo de progresión de la disfunción respiratoria (rápida o lenta) o del requerimiento específico para cada paciente (ventilación no invasiva o invasiva).

Introduction: Respiratory compromise in Pompe disease is one of the most frequent manifestations, which has a negative impact on quality of life and leads to multiple complications. This can occur as an evolutionary part of the disease, or even be the initial symptom of the pathology. Contents: Its clinical presentation is characterized by dyspnea, orthopnea, headache, and cough, and its paraclinical changes include hypercapnia, polycythemia, elevated apnea/hypopnea index, decreased vital capacity, and decreased maximum inspiratory and expiratory pressures. Respiratory compromise is caused mainly by muscular dysfunction (especially the diaphragm) and alteration of regulation of the central nervous system. Conclusions: An initial careful assessment of respiratory patterns is essential, and of course their follow-up, that will depend of the type of progression of respiratory dysfunction (rapid or slow) or the specific requirement for each patient (non-invasive or invasive ventilation).

Relación entre dimensiones antropométricas de tronco y valores de espirometría / Association between anthropometric dimensions of trunk and spirometry indices

Los objetivos del presente estudio fueron primero evaluar la asociación de dimensiones antropométricas de tórax y tronco con índices espirométricos, segundo, ajustar una ecuación de predicción con dimensiones antropométricas de tronco y tercero, comparar nuestro modelo predictivo con dos ecuaciones diagnósticas. Se evaluaron 59 estudiantes universitarios entre 20 y 40 años, de ambos sexos, sin hábito tabáquico. Las variables consideradas fueron: edad, sexo, peso, estatura, diámetro transverso de tórax, diámetro anteroposterior de tórax, perímetro de tórax, altura de tórax, altura de tronco, flujo espiratorio máximo (FEM), volumen espiratorio forzado en el primer segundo (VEF1) y capacidad vital forzada (CVF). Se utilizó el análisis de regresión múltiple para estimar los valores espirométricos en función de las variables demográficas y antropométricas. La CVF y el VEF1 tienen asociación lineal directa con el diámetro transverso de tórax, altura de tórax, perímetro de tórax y altura de tronco. Se ajustó una ecuación de regresión lineal múltiple que indicó que es posible estimar la CVF y el VEF11 en función de la altura de tronco y el perímetro de tórax para ambos sexos. Estas variables son capaces de explicar el 74 % de los valores de CVF y el 68 % de los valores de VEF1. Al comparar los valores obtenidos por nuestras ecuaciones predictivas con las ecuaciones de referencia nacional observamos que nuestros resultados son más cercanos a los de Quanjer et al. (2012) que a los de Knudson et al. (1983). La altura de tronco y el perímetro de tórax tienen asociación directa con el VEF1 y CVF y son buenos predictores del VEF1 y CVF en estudiantes universitarios. Nuestros valores estimados son más cercanos a las ecuaciones de Quanjer et al. (2012) en comparación a las estimaciones de Knudson (1983).

SUMMARY: The purposes of the present study were first to evaluate the association between anthropometric dimensions of the thorax and trunk with spirometric indices, second, to fit a prediction equation with anthropometric dimensions of the trunk, and third, to compare our predictive model with two diagnostic equations. Fifty-nine university students between 20 and 40 years old, of both sexes and non-smokers were recruited. Variables considered were age, sex, weight, height, chest transverse diameter, chest anteroposterior diameter, chest perimeter, chest height, trunk height, maximum expiratory flow (PEF), forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC). Multiple regression analysis was used to estimate spirometric values based on demographic and anthropometric variables. FVC and FEV1 have a direct linear association with chest transverse diameter, chest height, chest circumference, and trunk height. A multiple linear regression equation was fitted, indicating that it is possible to estimate FVC and FEV1 as a function of trunk height and chest girth for both sexes. These variables can explain 74% of the FVC values and 68% of the FEV1 values. Comparing the values obtained by our predictive equations with the national reference equations, we observe that our results are closer to those of Quanjer et al. (2012) than to those of Knudson et al. (1983). Trunk height and chest circumference have a direct association with FEV1 and FVC and are good predictors of FEV1 and FVC in university students. Our estimated values are closer to Quanjer et al. (2012) than Knudson et al. (1983) prediction equations.

A comparison between propofol and sevoflurane for easy insertion of laryngeal mask airway among adults in minor elective surgeries: An observational study

Background: The laryngeal mask airway (LMA) has reached ample popularity for the management of airway during surgery. Propofol, used as induction agent, causes change in blood pressure and heart rate (HR) while insertion of LMA. Sevoflurane, whereas, has the potential to be a good induction agent as propofol. We have compared propofol and sevoflurane for easy insertion of LMA among adults in minor surgeries. Aim and Objectives: The primary objective of the study was to compare the ease of insertion of LMA and its characteristics related to insertion among adults in minor elective surgeries using intravenous propofol or inhalational sevoflurane. While time taken to set induction and actual event of LMA insertion along with number of attempts, jaw relaxation time, LMA insertion time, apnea time, monitoring hemodynamic changes, and occurrence of complications were taken as secondary objectives. Materials and Methods: It was a prospective and observational study done in Department of Anesthesiology and Operation Theaters of Fortis Hospital, Kolkata, after getting ethical approval. Total 100 patients were recruited by consecutive sampling and divided into two groups - P (propofol) and S (sevoflurane) group. Anesthesia induction time, jaw relaxation time, LMA insertion time, etc. were noted. LMA insertion conditions were assessed by a 3-point scale using six variables, total score was calculated for each group. Hemodynamic parameters and induction complications were also recorded. Results: There was no significant difference in demographic parameters, American Society of Anesthesiologists class, Modified Mallampati Grading, and LMA size, between the groups. LMA insertion time was comparable between the two groups. Regarding complications, there was no incidence of coughing while minor gagging (4%) and laryngospasm (6%) were noted only with sevoflurane. Final summation of scores showed excellent insertion characteristics with propofol (94%) and sevoflurane (84%), respectively, with no significant difference. Conclusion: Inhalational sevoflurane may be regarded as a viable alternative to inj. propofol for insertion of laryngeal mask among adults in minor elective surgeries.

Physical fitness and associated factors among primary and middle school students in Henan Province in 2019 / 中国学校卫生

Objective@#To understand physical fitness among primary and middle school students in Henan Province, so as to provide theoretical basis for physical fitness promotion among primary and middle school students.@*Methods@#Based on data of National Survey on Student Physical Fitness and Health in Henan Province in 2019, a total of 42 734 students were investigated. The Z value of each physical fitness index were calculated by Z method, physical fitness index (PFI) was obtained to reflect the physical fitness condition synthetically. Physical fitness of different groups were compared, and associated factors of PFI were analyzed by multiple linear regression.@*Results@#Lung capacity, grip strength, standing long jump, 50 m run, 50 m×8 shuttle run and PFI in boys were [(2 552.1±1 226.5)mL, (26.0±13.9)N, (171.0±43.7)cm, (9.3±1.8)s, (132.1±22.6)s, (1.4±3.6)], respectively, which were significantly higher than that of girls [(1 965.2±765.3)mL, (19.1±8.2)N, (142.4±26.6)cm, (10.5±1.4)s, (136.9±21.1)s, (-1.4±3.2)]( t =59.35,62.66,81.87,-74.92,-16.72,85.96, P <0.01). The seated forward flexion of boys [(7.0±7.5)cm] was significantly lower than that of girls[(11.8±7.1)cm], the difference was statistically significant ( t =-68.57， P <0.01). Significant sex differences were observed in physical fitness at different age ( P <0.01). There was a certain gap between urban boys and rural boys in terms of strength quality, endurance quality and flexibility quality, and the physical quality of urban girls was better than that of rural girls as a whole. The detection rates of poor eyesight, malnutrition, overweight and obesity, anemia and high blood pressure of primary and middle school students were 68.0%, 5.4%, 26.0%, 15.9% and 18.0%, respectively. Region, sex, age and nutritional status(malnutrition,overweight and obesity) were the influencing factors of PFI( β =-0.23,-2.92,-0.11,-1.19, -0.78 , P <0.05).@*Conclusion@#Physical fitness among primary and middle school students varies in gender, age group, region and disease condition in Henan Province. Scientific intervention should be administered, especially for rural, female students, senior students, undernourished and overweight and obese students, to improve health awareness and physical fitness.

Effect of respiratory filter on pulmonary function in occupational health examination / 中华劳动卫生职业病杂志

Objective: To explore the influence and significance of respiratory filter on the judgment of pulmonary function and the conclusion of occupational health examination in occupational health examination. Methods: From August to November 2020, 252 occupational health examinees were randomly selected as the research objects, and the lung function was examined with the respiratory filter bite and the straight cylinder bite without filter, respectively. The lung function examination indexes and the qualification rate of lung function examination were analyzed and compared between the two groups, and the diagnostic criteria of lung function examination was corrected. Results: 252 subjects were 36 (30, 42) years old. The qualified rate of lung function examination with respiratory filter bite (28.17%, 71/252) was lower than that with straight cylinder bite (34.92%, 88/252) , the difference was statistically significant (P<0.05) . The percentage of forced vital capacity in normal predicted value (FVC%) , percentage of forced expiratory volume in the first second in normal predicted value (FEV(1)%) , and percentage of forced expiratory volume in the first second in forced vital capacity (FEV(1)/FVC%) of subjects using respiratory filter bite were lower than those using the straight cylinder bite (P<0.05) . The corrected diagnostic criteria of pulmonary function were FVC%>78%, FEV(1)%>77%, FEV(1)/FVC%>68%. There was no significant difference between the qualified rate of the respiratory filter bite lung function test calculated according to the corrected diagnostic criteria (35.71%, 90/252) and the qualified rate of the straight cylinder bite lung function test calculated according to the original diagnostic criteria (34.92%, 88/252) (P>0.05) . Conclusion: In occupational health examination, the use of respiratory filter may affect the results of pulmonary function examination. The diagnostic criteria of pulmonary function can be corrected according to different filtering effects to ensure the accuracy of the conclusions of occupational health examination.

Deep learning for analysis of changes in vital capacity and blood markers after swimming matches based on blended learning / Aprendizado profundo para análise das alterações da capacidade vital e marcadores sanguíneos após jogos de natação baseados no aprendizado combinado / Aprendizaje profundo para el análisis de los cambios en la capacidad vital y los marcadores sanguíneos después de los partidos de natación basados en el aprendizaje combinado

ABSTRACT Introduction Nowadays, more people are concerned with physical exercise and swimming competitions, as a major sporting event, have become a focus of attention. Such competitions require special attention to their athletes and the use of computational algorithms assists in this task. Objective To design and validate an algorithm to evaluate changes in vital capacity and blood markers of athletes after swimming matches based on combined learning. Methods The data integration algorithm was used to analyze changes in vital capacity and blood acid after combined learning swimming competition, followed by the construction of an information system model to calculate and process this algorithm. Results Comparative experiments show that the neural network algorithm can reduce the calculation time from the original initial time. In the latest tests carried out in about 10 seconds, this has greatly reduced the total calculation time. Conclusion According to the model requirements of the designed algorithm, practical help has been demonstrated by building a computational model. The algorithm can be optimized and selected according to the calculation model according to the reality of the application. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO Introdução Atualmente, mais pessoas preocupam-se com o exercício físico e as competições de natação, como evento esportivo de destaque, tornou-se foco de atenção. Tais competições exigem atenção especial aos seus atletas e o uso de algoritmos computacionais auxiliam nessa tarefa. Objetivo Projetar e validar um algoritmo para avaliação das alterações da capacidade vital e marcadores sanguíneos dos atletas após os jogos de natação baseados no aprendizado combinado. Métodos O algoritmo de integração de dados foi usado para analisar as mudanças de capacidade vital e ácido sanguíneo após competição de natação de aprendizado combinado, seguido à construção de um modelo de sistema de informação para calcular e processar esse algoritmo. Resultados Experiências comparativas mostram que o algoritmo de rede neural pode reduzir o tempo de cálculo a partir do tempo inicial original. Nos últimos testes levados à cabo em cerca de 10 segundos, isto reduziu muito o tempo total de cálculo. Conclusão De acordo com os requisitos do modelo do algoritmo projetado, foi demonstrada a ajuda prática pela construção de um modelo computacional. O algoritmo pode ser otimizado e selecionado de acordo com o modelo de cálculo, segundo a realidade da aplicação. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción Hoy en día, cada vez más personas se preocupan por el ejercicio físico y las competiciones de natación, como evento deportivo destacado, se han convertido en un foco de atención. Estas competiciones requieren una atención especial para sus atletas y el uso de algoritmos computacionales ayuda en esta tarea. Objetivo Diseñar y validar un algoritmo para evaluar los cambios en la capacidad vital y los marcadores sanguíneos de los atletas después de los partidos de natación basado en el aprendizaje combinado. Métodos Se utilizó el algoritmo de integración de datos para analizar los cambios de la capacidad vital y la acidez de la sangre tras la competición de natación de aprendizaje combinado, seguido de la construcción de un modelo de sistema de información para calcular y procesar este algoritmo. Resultados Los experimentos comparativos muestran que el algoritmo de la red neuronal puede reducir el tiempo de cálculo con respecto al tiempo inicial. En las últimas pruebas realizadas en unos 10 segundos, esto redujo en gran medida el tiempo total de cálculo. Conclusión De acuerdo con los requisitos del modelo del algoritmo diseñado, se ha demostrado la ayuda práctica mediante la construcción de un modelo computacional. El algoritmo puede optimizarse y seleccionarse según el modelo de cálculo en función de la realidad de la aplicación. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

Functional physical training to improve the physical health of university students / Treinamento físico funcional para a saúde física de universitários / Entrenamiento físico funcional para la salud física de los estudiantes universitarios

ABSTRACT Introduction: Recently, the obesity rate in Chinese universities has increased substantially and the indicators of physical fitness have declined. The physical quality of college students is an alarming problem that cannot be ignored. The results of structured work could establish a basis for colleges and universities to formulate scientific functional physical training programs. Objective: Analyze the role of functional physical training in teaching physical education to male college students in colleges and universities. Methods: 116 male volunteer students from 4 colleges and universities were selected and divided into control and experimental groups. The groups received three physical education classes lasting 90 minutes for eight weeks. The experimental group received an additional 30 minutes of functional physical training. Both groups were tested for vital capacity, seated forward bending, standing long jump, 50-meter run, pull-up, and 1000-meter test. The tests were compared and statistica50-meteryzed. Results: After 1000-meters of training, the experimental group was superior to the control group on all measures except sitting forward flexion. The results showed significant changes (P<0.01). The restorative effect of the experimental group was significantly enhanced. There was no significant difference in body weight, BMI, 50-meter run, jump, vital capacity, pull-up, and other indicators before and after control training (P>0.05). Conclusion: The 8 weeks of functional physical training promoted a significant effect on improving the physical health of college students. Functional physical training should be appropriately reinforced in university physical education classes to improve students' physical fitness. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO Introdução: Recentemente, a taxa de obesidade nas universidades chinesas tem aumentado substancialmente e os indicadores de aptidão física têm diminuído. A qualidade física dos estudantes universitários é um problema alarmante que não pode ser ignorado. Os resultados de um trabalho estruturado poderiam estabelecer uma base para que faculdades e universidades possam formular programas científicos de treinamento físico funcional. Objetivo: Analisar o papel do treinamento físico funcional no ensino da educação física de estudantes universitários do sexo masculino em faculdades e universidades. Métodos: Foram selecionados 116 estudantes voluntários do sexo masculino em 4 faculdades e universidades, divididos em dois grupos: controle e experimental. Os grupos receberam três aulas de educação física com duração de 90 minutos durante oito semanas. O grupo experimental recebeu 30 minutos adicionais de treinamento físico funcional. Os dois grupos foram testados quanto à capacidade vital, flexão sentado para frente, salto em pé à distância, corrida de 50 metros, pull-up e teste de 1000 metros. Os testes foram comparados e analisados estatisticamente. Resultados: Após oito semanas de treinamento, o grupo experimental foi superior ao grupo de controle em todas as medidas, exceto a flexão sentado. Os resultados apresentaram alterações significativas (P<0,01). O efeito restaurador do grupo experimental foi significativamente aprimorado. Não houve diferença significativa no peso corporal, IMC, 50 metros de corrida, salto, capacidade vital, pull-up e outros indicadores antes e depois do treinamento controle (P>0,05). Conclusão: As 8 semanas de treinamento físico funcional promoveram um efeito significativo na melhoria da saúde física dos estudantes universitários. O treinamento físico funcional deve ser adequadamente reforçado nas aulas de educação física universitária para melhorar a aptidão física dos estudantes. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción: Recientemente, la tasa de obesidad en las universidades chinas ha aumentado considerablemente y los indicadores de aptitud física han disminuido. La calidad física de los estudiantes universitarios es un problema alarmante que no se puede ignorar. Los resultados de un trabajo estructurado podrían sentar las bases para que los colegios y universidades formulen programas científicos de entrenamiento físico funcional. Objetivo: Analizar el papel del entrenamiento físico funcional en la enseñanza de la educación física de los estudiantes universitarios varones en los colegios y universidades. Métodos: Se seleccionaron 116 estudiantes voluntarios varones de 4 colegios y universidades, divididos en dos grupos: control y experimental. Los grupos recibieron tres clases de educación física de 90 minutos durante ocho semanas. El grupo experimental recibió 30 minutos adicionales de entrenamiento físico funcional. Ambos grupos fueron sometidos a pruebas de capacidad vital, flexión hacia delante sentada, salto de longitud de pie, carrera de 50 metros, dominadas y prueba de 1000 metros. Las pruebas se compararon y se analizaron estadísticamente. Resultados: Tras ocho semanas de entrenamiento, el grupo experimental fue superior al grupo de control en todas las medidas, excepto en la flexión hacia delante en posición sentada. Los resultados mostraron cambios significativos (P<0,01). El efecto restaurador del grupo experimental fue significativamente mayor. No hubo diferencias significativas en el peso corporal, el IMC, la carrera de 50 metros, el salto, la capacidad vital, la dominada y otros indicadores antes y después del entrenamiento de control (P>0,05). Conclusión: Las 8 semanas de entrenamiento físico funcional promovieron un efecto significativo en la mejora de la salud física de los estudiantes universitarios. El entrenamiento físico funcional debe reforzarse adecuadamente en las clases de educación física de la universidad para mejorar la aptitud física de los estudiantes. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

Clinical efficacy of caspofungin combined with voriconazole in the treatment of older adult patients with pulmonary fungal infection / 中国基层医药

Objective:To investigate the clinical efficacy of caspofungin combined with voriconazole in the treatment of older adult patients with pulmonary fungal infection and its effects on pulmonary function and inflammatory factors.Methods:A total of 100 patients with pulmonary fungal infection admitted to Hangzhou Ninth People's Hospital from January 2016 to December 2020 were included in this study. They were randomly assigned to undergo treatment with either voriconazole (control group, n = 50) or caspofungin combined with voriconazole (observation group, n = 50) for 14 consecutive days. Clinical efficacy and changes in pulmonary function and inflammatory factors after treatment relative to before treatment were determined in each group. Results:Total response rate in the observation group was significantly higher than that in the control group [90.00% (45/50) vs. 74.00% (37/50), χ2 = 4.33, P < 0.05). After treatment, forced vital capacity, forced expiratory volume in 1 second, and maximum expiratory flow rate in the observation group were (2.31 ± 0.77) L, (79.30 ± 6.72)%, (86.14 ± 7.27)%, respectively, which were significantly higher than (1.78 ± 0.74) L, (73.22 ± 6.56)%, (78.16 ± 7.09)% in the control group ( t = 3.50, 4.57, 5.55, all P < 0.05). Tumor necrosis factor α, interleukin-6, and procalcitonin levels in the observation group were (8.32 ± 1.41) ng/L, (35.19 ± 3.40) μg/L, (1.94 ± 0.78) ng/L, respectively, which were significantly lower than (10.15 ± 1.58) ng/L, (46.09 ± 3.64) μg/L, (2.43 ± 0.84) ng/L in the control group ( t = 6.11, 15.43, 3.02, all P < 0.05). The incidence of adverse reactions in the observation group was 4.0% (2/50), which was significantly lower than 18.0% (9/50) in the control group ( χ2 = 5.00, P < 0.05). Conclusion:Caspofungin combined with voriconazole for the treatment of pulmonary fungal infection in older adult patients can effectively improve pulmonary function, inhibit the inflammatory response, and have no obvious adverse reactions with accurate clinical efficacy.

A Study to Evaluate the Effect of Chyavanprash in Elderly People Having Low Vital Capacity

Ageing is a natural process. Senescence is an expression used for the deterioration in the vitality or the lowering of the biological efficiency that accompanies ageing. Respiratory system undergoes various anatomical, physiological and immunological changes with age. Lungs mature at age 20 to 25 years, and then it decreases about 200 to 250cc every 10 years from 20 years of age. Among elderly health problems, respiratory conditions make 16.1% of the complaints. Chyavanprash, one of the foremost Rasayana is specifically indicated for elderly people. This would be the remedy for improving the respiratory system functioning in aged people, if it could prove the effect in enhancing the vital capacity. Individuals of age 50 years and above were screened by using computerized spirometer. From these, 67 individuals with reduced vital capacity were selected for the study. Spirometric assessment was done. After the assessment, Chyavanprash was administrated. Dosage was fixed as 10gm for a period of 1 month. After 1 month spirometric assessment was done. This shows that there exists a positive response in vital capacity to Chyavanprash. Rasayana, Brmhana, Tridoshahara, and Balya properties evoked a positive response in vital capacity.

EFFECT OF SELECTED YOGIC PRACTICES ON VITAL CAPACITY AMONG COLLEGE STUDENTS

The purpose of the study was to find out the effect of selected yogic practices on vital capacity among college students. To achieve this purpose of the study, forty male students were selected as subjects who were from the various Department of Ewing Christian College, Prayagraj. The selected subjects were aged between 17 to 19 years. They were divided into two equal groups of twenty each, Group I underwent yogic exercise practice and group II acted as control that did not participate in any special training apart from their regular sports and games practices. The subjects were tested on selected criterion variables such as vo2 max prior to any immediately after the training period. The selected criterion variable such as vo2 max was measuring by queen's college step test. The analysis of covariance (ANCOVA) was used to find out the significant differences if any, between the experimental group and control group on selected criterion variable. The 0.05 level of confidence was fixed to test the significance, which was considered as an appropriate. The result of the present study has revealed that there was a significant difference among the experimental and control group on vo2 max.

An Exploration of Pulmonary Fitness of Construction Workers in Delhi NCR in Light of the Building and Other Construction Workers Act, 1996

Workers in the construction sector are exposed to high concentrations of particulate matter at their workplace. This increases their susceptibility to various respiratory diseases, particularly chronic obstructive pulmonary disease (COPD) and acute respiratory distress syndrome (ARDS). The study reports comparative pulmonary fitness and hematological parameters of the migrant workers in the construction sector versus other sectors in Delhi. Parameters such as forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1 ), the ratio of FEV1 to FVC, and peak expiratory flow were measured in both groups using a spirometer. We observed significant differences (P < 0.05) in FEV1 and FVC between both groups. The study thus confirms that workers exposed to poor air quality at the construction site are susceptible to respiratory diseases, particularly ARDS. All of this reflects the poor enforcement of the adequate safety measures well enlisted in social legislations such as the Building and Other Construction Workers Act.

Assessment of pulmonary functions FVC, FEV1, and FEV1/FVC ratio among athletes and non-athletes

Background: Pulmonary function will improve by regular and intense physical activity. There will be difference in degree of improvement or increase in pulmonary functions in different types of athletic activities. Recent studies have stated forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and FEV1/FVC ratio to be higher in athletes than in the normal sedentary control individuals. Few studies have found lower values of dynamic pulmonary function while few other studies have found higher values of dynamic pulmonary function tests. We undertook this study to know the pulmonary function in athletes of Bengaluru and compare it with controls. Aim and Objective: This study aims to record dynamic pulmonary function tests (FVC, FEV1 and FEV1/FVC) using COSMED computerized spirometer in athletes and to compare with non-athletes. Materials and Methods: This is a case朿ontrol study which included 50 non-smoking athletes of 18� years age group from Shree Kanteerava Stadium, Bengaluru, and 50 non-athletes as control group after considering inclusion and exclusion criteria. Subjects were age and gender matched. FVC, FEV1, and FEV1/FVC were recorded using COSMED computerized spirometer. For statistical analysis, independent Student抯 t-test was used. Results: FVC, FEV1, and FEV1/FVC (P < 0.001) were significantly increased in athletes than non-athletes. Conclusion: Regular exercise and athletic training will improve the lung function tests.

Gender differences in peak expiratory flow rate and timed vital capacity by computerized spirometry in medical students

Background: Throughout the human life span, airway behavior and the clinical manifestations of airway disease show gender differences which are related to other factors such as biological and sociocultural factors. Similar studies have been conducted in various parts of India and showed wide variations even within the state with similar socioeconomic and cultural factors. Even physical activity too has influenced pulmonary function tests (PFT). The most of the studies on PFT were carried out in the Southern part of Karnataka and no previous studies on this topic were done in Bidar. Aim and Objectives: The aim of the study was to study the gender differences in peak expiratory flow rate (PEFR) and timed vital capacity among medical students of BRIMS, Bidar. Materials and Methods: After obtaining ethical clearance from institute, the study was conducted on healthy 18� years aged 200 males and 200 female undergraduate medical students in Department of Physiology, BRIMS, Bidar. After recording basic physical characteristics, lung parameters that are forced vital capacity (FVC), forced expiratory volume in the 1st s (FEV1), FEV3, and PEFR were recorded using Micro Quark, a PC-based spirometer, connected through serial port (RS232). Statistical analysis was done using independent sample t-test with the help of SPSS 25 version. P < 0.05 was considered the level of significance. Results: Results revealed that there was statistically significant decrease in the mean values of FVC(L), FEV1(L), FEV3(L), and PEFR (L/min) in female subjects compared to male subjects (P < 0.01). Even there was statistical significant decrease in FEV1/FVC ratio in female subjects compared to male subjects (P < 0.05). Conclusion: Our study concluded that the values of FVC, FEV1, FEV3, FEV1/FVC, and PEFR were observed to be higher in male undergraduate subjects when compared with female subjects of BRIMS, Bidar.

Comparison of the effect of recumbent body positions on dynamic lung function parameters in healthy adults

Background: Pulmonary function parameters can be altered with the change in body position. Therefore, physiological basis behind such consequent influence is essential to be understood. Pulmonary function tests are generally conducted in the erect sitting posture as it is more feasible and comfortable. However, bedridden patients are unable to do so and only few studies are found on recumbent postures. Thus, to comfort such patients in breathing, need arises to meet this requisite investigation to conclude the best recumbent body posture. Aim and Objectives: To compare and assess forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC ratio, forced expiratory flow of during 25�% expiration (FEF25�%, and peak expiratory flow rate (PEF) in the Supine, Crook-lying and Fowler抯 position. Materials and Methods: The present research was carried out on 128 healthy adults to measure FVC, FEV1, FEV1/FVC ratio, FEF25�% and PEF using a computer-based spirometer in the Supine, Crook-lying and Fowler抯 position. One-way Analysis of Variance with Tukey HSD post-hoc test was utilized between each body postures by evaluation of their mean values. Results: This study consisted of 128 subjects (males 57, females 71) with mean age of 21.62 � 1.75 years, mean weight 59.71 � 9.97 kg, mean height 164.68 � 9.30 cm and Body mass index 21.91 � 2.38 kg/m2. Fowler抯 posture showed significantly (P < 0.05) higher value in all spirometric parameters as compared to other two postures. Outcome of the study showed all spirometric parameters value- greater in the Fowler抯 posture than that of Supine or Crook-lying posture. Conclusion: The implication of this research is that it will meet the need of selection of the most suitable substitute posture for better pulmonary functioning in bedridden people.

Waist circumference and waist-hip ratio as a predictor of respiratory risk factor

Background: The prevalence of Abdominal Obesity as well as of Generalized Obesity are high in India. Obesity can directly alter respiratory physiology through a variety of processes and can lead to reduction in lung function. The quantity and location of body fat alter the impact of obesity on pulmonary function. Waist circumference (WC) links to intra-abdominal and subcutaneous fat and it is a better scale of intra-abdominal fat. Aim and Objectives: (1) To determine the effect of anthropometric parameters like WC, waist-hip ratio (WHR) on timed vital capacity in adult. (2) To determine the difference in timed vital capacity between males and females. Materials and Methods: 150 apparently healthy adults aged 20� years were selected for the study. WC, Waist-hip ratio were measured. Pulmonary functions such as Forced Vital Capacity, Forced Expiratory Volume in one second, (FEV1/FVC%) were recorded using Computerized Spirometer (RMS HELIOS 401). Data were statistically analyzed by unpaired t-test, Karl Pearson抯 coefficient of correlation test, statistical significance was considered for P < 0.05. Results: FVC, FEV1 were significantly declined in both male and female subjects in the group II compared to group I in terms of both WC and WHR. FVC, FEV1were significantly higher in males when compared with females. Significant negative correlation observed between FVC and FEV1 values with Group II of WC and WHR. Conclusion: To conclude obesity even in the absence of specific pulmonary disease, alters the pulmonary function, that can lead to long-term consequences. Regular exercise, yoga, pranayama help to reduce weight and improve breathing by strengthening respiratory muscles.

Effects of passive smoking on pulmonary functions of individuals in an urban area

Background: Passive smoking is a world health problem and part of the tobacco epidemic which victimizes mostly adolescents. Research articles have addressed the relation between passive smoking and respiratory efficiency in adult population and escalated the hazard of chronic obstructive pulmonary disease and lung cancer among adult passive smokers. The present study was conducted to analyze the effects of exposure to passive smoke on pulmonary functions among nonsmoking individuals. Aim and Objectives: The study was determined to assess the effects of passive smoking on pulmonary functions among individuals in urban region. Materials and Methods: The present study was conducted on smokers, passive smokers, and nonsmokers (control), aged between 17 and 25 years. Ninety healthy individuals were placed in three different groups on the basis of questionnaire (Group A: active smoker, Group B: passive smoker, Group C: control). Study was done with the help of spirometer and pulse oximeter. Results: Forced expiratory flow25–75%, Forced expiratory volume in 1 second/Forced vital capacity % values were significantly reduced in passive smokers as compared to control individuals (P < 0.001, P < 0.05). SpO2 level was decreased in passive smokers and active smokers, but it was not statistically significant. Conclusions: The present study showed a strong association between passive smoking and pulmonary abnormalities in individuals exposed to passive smoke. Health hazards caused by passive smoking should be controlled by creating awareness and regular health check-ups among people.

Liver function tests in patients with chronic obstructive pulmonary disease in a tertiary care hospital

Background: Cases of chronic obstructive pulmonary disease (COPD) increasing day by day. Smoking is the major causative agent for COPD. The present study undertaken to estimate the deterioration of liver functions in COPD patients due to smoking. Aims and Objectives: This study aims to investigate various liver function tests (LFTs) such as total bilirubin, alanine amino transferase/serum glutamic pyruvic transaminase (SGPT), aspartate amino transferase/SGPT, alkaline phosphatase (ALP), serum ammonia, and serum albumin among COPD patients. To correlate LFTs with forced expiratory volume at end of 1 second (FEV1) and FEV1/Forced vital capacity (FVC) ratio. Materials and Methods: In our present study, we selected 86 cases of COPD in the age group of 41–60 years. All subjects were smokers and having FEV1 <80% and FEV1/FVC <70%. A control group consists of 55 healthy individuals. LFTs were studied. FEV1 and FEV1/FVC ratio were correlated with LFTs. Statistical analysis done using SPSS software 20.0 Windows version. Results: Mean level of SGPT among cases was 117 ± 10.23 IU/L against controls who had mean SGPT 11.16 ± 8.32 which was statistically significant (P < 0.05). Likewise, mean level of s. ammonia among cases was 154 ± 10.22 mcg/dl as compare to controls who had mean 24.43 ± 7.97 mcg/dl (P < 0.05). However, no significant difference was found in rest of the LFTs. Furthermore, there was no correlation between altered LFTs and severity of COPD. Conclusion: LFTs are significantly altered in COPD patients due to smoking. Corticosteroids treatment must not be initiated without investigating LFTs among COPD patients.

COMPARATIVE STUDY OF PHYSIOLOGICAL CHARACTERISTICS AMONG NATIONAL LEVEL KABADDI PLAYERS OF DIFFERENT GEOGRAPHICAL REGIONS IN INDIA

Introduction: The objective of this study was to investigate the physical characteristics among national level kabaddi players of different geographical regions in India. Another purpose of the study was to ?nd out the physiological characteristics among national level kabaddi players of different geographical regions in India. Methods: The subjects for the study were selected from the 150 male national level kabaddi players. 50 subjects were selected from coastal area, 50 subjects were selected from non-coastal area and while another 50 subjects was selected from hilly area. The age level of subjects was range from 20 to 25 years. All the subjects were residing at different geographical regions in India. A stand and progressive matrices organizational selected physiological characteristic is (Vital Capacity, Respiratory Rate, Blood Pressure and Pulse Rate). To ?nd out signi?cant different of physiological characteristics among national level kabaddi players of different geographical regions in India, the one-way analysis of variance was used. The level of signi?cance was set at .05 levels. The result reveals the one-way analysis of variance that there was signi?cant (p>.05) for Results And Discussion: physiological characteristics (Vital Capacity, Respiratory Rate, Blood Pressure and Pulse Rate) among national level kabaddi players of different geographical regions in India.

A study of correlation of pulmonary function test in patients with metabolic syndrome with different components of metabolic syndrome

Background:The increasing incidence of metabolic syndrome has been on the rise especially in urban population and leading to increased risk of cardiovascular disease (CVD) and diabetes mellitus. It has been associated with impairment of pulmonary functions. However, there is limited data regarding the association with individual components of metabolic syndrome and overall effect on components of pulmonary functions.Methods:This is a cross sectional study consisting of 50 subjects with metabolic syndrome. All the subjects underwent pulmonary function tests and the association between different components of metabolic syndrome and pulmonary function were examined using unpairedt-test and Pearson抯 partial correlation coefficient. This data was analysed by using statistical package for the social sciences (SPSS) version12.0.Results:In females, moderate negative significant correlation was seen between forced vital capacity (FVC)and systolic blood pressure (SBP), diastolic blood pressure (DBP),fasting blood sugar(FBS), triglyceride (TG), waist circumference (WC)and body mass index(BMI)whereas positive weak non-significant correlation was seen between FVC and high density lipoprotein cholesterol (HDLC), while no such relation was found with forced expiratory volumein one second (FEV1). In males, negative, moderate significant correlation was seen between FVC and FBS whereas strong, positive, significant correlation was seen between FVC and WC; between FVC and BMI. Negative, moderate, significant correlation was seen between FEV1 and WC; between FEV1 and BMI.Conclusions:Our study concluded that there was a significant impact of FBS and WCon decreasing FVC on both genders with minimally significant impact of other components of metabolic syndrome on FVC with no effect on FEV1 hence indicatinga restrictive pattern of pulmonary function derangement. Hence, further studies with larger sample size isneeded to confirm whether there are direct or indirect mechanisms through which insulin resistance could affect pulmonary function.

Effect of pranayama training on vital capacity, respiratory pressures, and respiratory endurance of young healthy volunteers

Background: There is a paucity of literature on the effects of isolated pranayam practice in particular savitri pranayam. Furthermore, no study depicts the pattern of change and variations in the effects produced. It needed to be found out whether long-term practice of Pranayama improves respiratory endurance and to what extent. Aim and Objectives: The aim of the study was to determine forced vital capacity (FVC), forced expiratory volume in 1stsecond, maximum inspiratory pressure, maximum expiratory pressure, and 40 mm Hg endurance of young healthy volunteers and to study the effect of pranayam on the same. Materials and Methods: Sixty volunteers of age group 20–30 were recruited and were divided into pranayam group and control group. After familiarizing the subjects with lab environment, the pre training values of both the groups were recorded. The parameters recorded were FVC, Forced expiratory volume in 1st s, maximum inspiratory pressure, maximum expiratory pressure, and 40 mm Hg endurance. A spirometer and a mercury manometer were used to measure these parameters. The pranayam group was given training in savitri pranayam for 12 weeks. The parameters were recorded at 4, 8, and 12 weeks of study. Data were collected and analyzed with student-t-test. Tests of significance were calculated by Statistical package for the Social Sciences software version 21.0. Results: There was a highly significant improvement (P < 0.001) in all the parameters among pranayam group. The control group did not showed significant improvement in any of the parameters. Conclusion: The improvement in respiratory efficiency in this study, though highly significant is less in magnitude. Combined practice of asan and pranayam may produce a better improvement than practicing savitri pranayam alone. The pattern of improvement in respiratory variables is not uniform. Individuals respond differently to yoga. Some showed a rapid improvement followed by a plateau, whereas for others the improvement graph appeared slow and steady. Yoga training has to be individualized and yoga therapy should be customized according to individual patient’s receptivity and nature. Savitri pranayam would be an effective tool in promotion of respiratory efficiency.